I have been director of Micron since 2007 as well as Principal Investigator of my own lab. In the past my lab has focussed on how mRNA transport and localised translation impacted on Drosophila embryonic axis specification. In recent years we have expanded our interest to include the same basic molecular processes to the Drosophila nervous system, in particular the brain and neuromuscular junction.
In order to achieve our scientific aims we use a wide range of scientific techniques, including advanced imaging techniques as well as an array of genetic and biochemistry-based methods.
Micron Deputy Director
The main goal of Jordan Raff's research is to understand how centrioles and centrosomes function at the molecular level. Centrioles organise the assembly of two important cell organelles: centrosomes and the cilia; our goal is to understand how these organelles function at the molecular level. Centrosomes are the major microtubule (MT) organising centres in many animal cells, and they have an important role in cell division, in establishing and maintaining cell polarity and in positioning and transporting molecules and organelles within the cell.
Martin's research centres on the development of adaptive optics to compensate for optical abberations caused by focussing through a specimen. These adaptive optics techniques were originally developed for astronomical research, for stabilising and de-blurring telescope images of stars and satellites. Such images are affected by the optical distortions introduced by turbulence in the Earth's atmosphere. Recent technological developmentsmean that this technology is now being adapted for more down-to-Earth reasons. This has opened up the possibility of using adaptive optics in these smaller scale applications.
The main research interests of my laboratory are focused on the application and development of ultra-sensitive, live-cell fluorescence microscopy techniques with a spatial resolution down to the molecular level (super-resolution microscopy or nanoscopy), superior to conventional optical microscopes. These super-resolution microscopes will be used to unravel nanoscopic changes at the molecular level in living cells following cellular immune responses.
Yvonne Jones is Director of the Cancer Research UK Receptor Structure Research Group which is focused on the structural biology of extracellular recognition and signalling complexes. The group's core techniques include protein crystallography and, increasingly, cryo electron microscopy, which are used to generate high resolution structural information.
Our group works on how cell movement is controlled during mouse embryogenesis, particularly focusing on the following problems:
Micron Group Leader
2003 PhD at the Ludwig Maximilians University Munich (Advisor: Prof. Thomas Cremer)
2003-2011 Postdoctoral Researcher / Lecturer, Faculty of Biology, Ludwig Maximilians University Munich (Advisor: Prof. Heinrich Leonhardt).
2005/2007 Visiting Scientist with Prof. John W. Sedat, University of California, San Francisco.
Since 2011 Micron Senior Research Fellow / Principle Investigator at the Department of Biochemistry, University of Oxford
The central theme of my research is to understand the three-dimensional (3D) organisation of chromatin and its impact on the regulation of genome activity, using advanced optical imaging methods. As postdoctoral researcher and then co-investigator I pioneered the biological application of super-resolution 3D structured illumination microscopy (3D-SIM), and led the development of live cell imaging methods to interrogate various aspects of (epi)genome biology (e.g. chromosome dynamics, DNA methylation regulation). Since becoming Micron Senior Research Fellow and Principle Investigator at the Oxford University in 2011, my team and I have extended 3D super-resolution imaging to increase throughput, study living cells and combine it with photo-kinetic manipulation. Our contributions were essential in collaborative projects to study double-strand break repair in E.coli, to investigate the spatio-temporal events that lead to the assembly of mitotic centrosomes in Drosophila, and to unveil spatial relationships of factors involved in mammalian X-chromosome inactivation. We also developed computational analysis tools for standardised quality control as well as improved fluorescence in situ hybridisation protocols for 3D-SIM. The main focus of our research has recently shifted towards understanding the contribution of functional chromatin landscapes and topological domain organisation in regulating genome activity. Specifically, we aim to gain a better understanding of the interplay between biophysical forces, epigenetic memory and cohesin complex activity to modulate cell type/stage specific transcriptional programmes. To this end we employ a combination of genetic editing with innovative live-cell and correlative super-resolution imaging and analysis approaches. Our activities are supported by our embedding into the Micron Advanced Bioimaging Unit and our strong links to leading chromatin and epigenetic research groups within the Department and across Oxford.
Mike Dustin studies the immunological synapse using advanced imaging techniques. See Michael's website for more details. https://www.kennedy.ox.ac.uk/team/michael-dustin
I am a physicist by training with strong interest in the physical functioning of biological systems. My research at the interface of physics, biology, and immunology combines theoretical and experimental concepts to study the impact of a vital cytoskeleton in immunity. Having had a steep transition from theoretical physics to cell bio-immunity, my research aims to join state of art imaging modes and computation analysis methods to address the most challenging biomedical research questions from a bio-physical perspective: We are taking highly interdisciplinary approaches to investigate cytoskeleton-driven cellular processes in immunity and disease.