Leica Mica

The Mica is a fully automated multi-model microscope consisting of both confocal and widefield capabilities with intelligent optimisation of imaging parameters. The system allows for true simultaneous imaging in 4 channels in widefield mode with an easy switch to confocal imaging if required. The system is fully equipped for both short-term live cell imaging and long-time lapse experiments. Applications include cell biology, cancer research, live cell imaging, organoids, spheroids, expansion microscopy and other 3D cell culture models. The system is particularly well suit to fast tile scanning of tissue sections. AI supported analysis and computational clearing for widefield (Thunder algorithm). The system is also capable of colour imaging on histology samples. For access please contact micron@bioch.ox.ac.uk.

Specifications

• Fully automated inverted microscope
• 4 fold LED (405nm, 488nm, 561nm, 638nm)
• 4 colour simultaneous widefield imaging (FluoSync detection)
• Transmitted light detection and IMC
• 4-fold lasers (405nm, 488nm, 561nm, 638nm) 
• Confocal detection (FluoSync) 
• Adaptive Focus Control (AFC) 
• Aivia based image analysis with Pixel Classifier 
• Objectives: 1.6x, 10x, 20x, 63x water (automated water dispenser) 
• 3x Exclusive computation methods for widefield
• Lightning adaptive deconvolution for confocal 
• Inserts: universal, petri-dish, multi-well 
• Incubation: temperature, humidity, CO2 

Image Acknowledgement 

Sample and imagesare courtesy of Giulia Di Muzio at the lab of Dr. Pei-Chi Wei at the DKFZ, Heidelberg, Germany.

Access to Micron User Guides (requires Oxford SSO)